I am tired too often
or crash before the day is done.
Dr. Kuo's longevity method.
Applied to your health history.
One AI-generated report on what changed, what may be connected, what may deserve attention and what to discuss next with your medical team.
How your information becomes an analysis
Clinical Brain works with the supported records, labs, wearable data, history and goals you provide. It connects that information over time and compares relevant patterns across 300,000 case records, using a reasoning framework trained and shaped by Dr. Jonathann Kuo.
The result is an individualized longevity report to discuss with your medical team—or, if and when KuoX18 activates the service, a verified qualified reviewer.
Dr. Kuo shapes the reasoning. 18.health builds the system. Your information supplies the context.
“Case record” means an entry in the comparison corpus—not 300,000 unique patients and not cases personally assessed by Dr. Kuo.
Start with
what has changed.
You wake tired. Recovery takes longer. Your weight will not move despite the effort. Focus fades before the day is done.
Rest is not restoring me
the way it used to.
My weight or body composition is
not moving despite the effort.
The workouts I used to finish are
harder to complete.
My clarity runs out
before my responsibilities do.
I feel different in midlife
and want a clearer view of the change.
These changes belong
in your health story.
These starting points organize your route. They do not diagnose a condition.
DR. JONATHANN KUO, MD
The physician
behind the method.
Founder.
Longevity innovator.
From treating pain
to advancing longevity.
Dr. Jonathann Kuo founded Hudson Health and Extension Health, bringing together his work in interventional, regenerative and longevity medicine.
Double-board certified in anesthesiology and pain management, he combines a physician’s clinical perspective with a focus on how health changes over time.
50,000+
Patients treated across
his clinical network*
2
Board certifications
Anesthesiology · Pain management
Training & clinical leadership
Dr. Kuo earned his medical degree at Boston University. His training includes a residency at NewYork-Presbyterian / Weill Cornell and a fellowship spanning NewYork-Presbyterian, Hospital for Special Surgery and Memorial Sloan Kettering Cancer Center.
He is the founder of Hudson Health and the founder, CEO and Chief Medical Officer of Extension Health.
*Network-wide figure reported in his official biography; not patients personally treated by Dr. Kuo or reports reviewed through Clinical Brain.
His method.
Your health history.
Clinical Brain applies Dr. Kuo’s documented longevity reasoning framework to the information you provide: what to connect, what to question and what to leave uncertain.
Dr. Kuo shapes the reasoning. 18.health builds the system.
He does not personally review your report.
Your history connected.
Relevant cases compared.
Clinical Brain builds the context needed to examine your health information over time.
01 / YOUR CONNECTED HISTORY
Connect your history.
The knowledge graph connects your supported sources, dates, results, interventions, wearable signals, goals and lived changes into one time-ordered health history. It shows what changed and what changed around it, without treating every relationship as a cause.
02 / YOUR CONNECTED HISTORY
Compare relevant journeys.
The medical digital twin compares relevant aspects of your structured journey with patterns from 300,000 case records. It looks for useful similarities, important differences and bounded what-if paths.
03 / YOUR CONNECTED HISTORY
Bring the findings together.
The Kuo-trained reasoning framework brings your connected history and relevant comparisons into one source-aware analysis. It keeps uncertainty visible and produces the report.
01 / CONNECT YOUR HISTORY
RecordsResultsInterventionsWearablesGoals
SOURCE → TIME → CONTEXT → ANALYSIS
You are unique.
We find the closest medical digital twin.
From more than 300,000 case records, we match the closest medical digital twins to bring more context to your analysis and help shape your proposed longevity plan for discussion with your medical team.
What comparison can reveal
Clinical Brain uses relevant patterns from its medical-digital-twin corpus to widen the questions worth asking. Similarities suggest where to look; differences help show where a comparison may not apply.
The purpose is to give your analysis more context—not to assume that another person's experience will become yours.
Another person's path can inform your analysis; it cannot determine your outcome.
The comparison corpus contains more than 300,000 case records. A case record is an entry in the comparison corpus, not necessarily a unique patient or a case personally assessed by Dr. Kuo.
01 / DISTINCT JOURNEYS
REFERENCE CASEYOUR DIGITAL MEDICAL TWINREFERENCE CASE
Start with your health story.
Bring your history and goals into one Clinical Brain analysis, shaped by Dr. Kuo's longevity method. Receive an individualized AI-generated report for the next conversation with your medical team.
Inside your report
Your AI-generated report is intended to show:
- what changed, and when;
- what moved together, without assuming cause;
- where your journey resembles relevant patterns from 300,000 case records;
- where it differs and why that matters;
- gaps, conflicts, alternatives and uncertainty;
- what may deserve attention;
- what to discuss next with your medical team—or, if and when KuoX18 activates the service, a verified qualified reviewer.
Where supported, the report may include possible diagnoses or differential considerations. These remain AI-generated possibilities for qualified review—not a final diagnosis, prescription or treatment plan.